ABOUT ICARUS-IBD
ICARUS-IBD is a global study lead by researchers from the Translational Gastroenterology Unit at the University of Oxford and the Icahn School of Medicine at the Mount Sinai Hospital.
What is the purpose of the study?
The study focuses on inflammatory bowel disease (IBD) patients who are being treated with immunosuppressive drugs, specifically biological therapies (such as vedolizumab and infliximab). We will follow IBD patients who will be attending infusion centres for routine infusion treatments. We will report on sero-prevalence (number of persons in a population who test positive for a disease based on serology (blood serum) specimens) over time, risk factors for infection and outcomes of COVID-19 exposure in these patients. We will also report on how these patients respond to vaccination, comparing vaccines currently available in their respective countries.
Objectives
The study objectives are to:
(1) determine the seroprevalence and incidence over time of antibodies to SARS-CoV-2 in IBD patients receiving infusion medications,
(2) identify social, clinical, treatment-related, biologic factors that associate with seropositivity and asymptomatic disease, and
(3) characterize the systemic immune response to SARS-CoV-2 in these patients
OUR COLLABORATORS
University of Oxford, UK
Barts Health NHS Trust, UK
Icahn School of Medicine at Mount Sinai, USA
Miami University, USA
University of Chicago, USA
Mount Sinai Hospital, University of Toronto, Canada
Örebro University Hospital, Sweden
University Hospitals Leuven, Belgium
Hôpital Saint-Louis, France
All India Institute of Medical Sciences, India
Post Graduate Institute of Medical Education & Research, India
Chinese University of Hong Kong, Hong Kong
Hyogo College of Medicine, Japan
INVESTIGATORS
Professor Jack Satsangi
Lee Placito Professor of Gastro-intestinal Disease at the University of Oxford
Dr Serre-Yu Wong
Instructor of Medicine (Gastroenterology) at the Icahn School of Medicine at Mount Sinai
Professor
Jean-Frederic
Colombel
Director of the Helmsley IBD Center at Mount Sinai
Professor Séverine Vermeire
University Hospitals Leuven
Professor Matthieu Allez
Hôpital Saint-Louis
Dr Mark Silverberg
Mount Sinai Hospital, University of Toronto
Professor Vineet Ahuja
All India Institute of Medical Sciences
Professor Jonas Halfvarson
Örebro University Hospital
Professor James Lindsay
Barts Health NHS Trust
Dr Kenji Watanabe
Hyogo College of Medicine
Professor Siew Chien Ng
Chinese University of Hong Kong
Professor
David Ruben
University of Chicago
Professor
Maria Abreu
University of Miami
Professor
Usha Dutta
Post Graduate Institute of Medical Education & Research